In particular, the FFC composed of an autoregulated originating regulator and an autoregulation-less intermediary regulator was a significant antimotif common to TF and effecter target genes.
Two-thirds of the evolutionary paths from a common ancestor to the two yeast strains would have avoided this less fit intermediary and would therefore have been allowed by selection (Orr 1995).
Incompatibilities between three or more loci are theoretically expected to be more common than incompatibilities between two loci, because a greater proportion of evolutionary paths to higher-order incompatibilities do not pass through a less fit intermediary (Orr 1995).
Parties began to see themselves less as intermediaries between people and power, and instead settled into the fringes of the state apparatus.
The shift towards advertising and coordinating the sale of sex online means that prostitutes rely less on intermediaries, such as brothels and agencies, pimps and madams.
That version is one in which the state hands culture down to the people via its more or less underpaid intermediaries — the Egyptian artists and intellectuals who can hardly hope to make a living otherwise.
And if the banking system is defined to include all the less regulated intermediaries such as off balance sheet vehicles, the collapse in the supply of credit is unmistakable.
As the sociologists would have it, however, technological tools and political instruments "are less inert intermediaries than partly autonomous actants that contribute to orientating actors' behaviours" (Amicelle et al. 2015).
If a collaborative approach is pursued, it could also provide options for smaller, less-resourced intermediaries, ensuring that when individuals operate across multiple platforms, there is some institutional memory and coordination to prevent either under- or over-determination of individual requests.
But while it may be less obscure in intermediary steps between pilots, audiences and full productions runs, the shows Amazon takes to series don't always add up in terms of the tale of the tape via reviews and views (Bezos wants some Emmys, too).
