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ADVANCE aimed for an HbA1c ≤6.5% using a less intensive approach based on the sulfonylurea gliclazide.
An alternative, and computationally less intensive approach, is to introduce protein side chain flexibility during the ligand docking process.
There were some differences in the response to CGM when it was implemented with a less intensive approach to follow-up contacts.
This is likely to result in a more conservative, less intensive, approach to selecting the chemotherapy regimens for older patients (see below), as well as – for interpretation of the OS – less frequent use of all available drugs in subsequent treatments.
However, these national guidelines are generic, covering all types of exercise in a variety of patients, whilst CBE, as defined through this study, is useful for those who cannot participate in other forms of exercise and therefore a less intensive approach in this context may be reasonable.
However, some of the more recent trials questioned safety, reproducibility, and universality of beneficial effects of tight glycemic control (TGC) in other subgroups of critically ill patients [ 5– 7], leading consequently to a shift towards a less intensive approach to glucose lowering in ICU settings in the last years.
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Subsequent comparison of allele frequency distributions in multiple population genomic samples could further test these signatures, and such data could also be used to refine less intensive approaches to identifying selection in pathogens with large genomes.
In practical terms this means a program that reaches young people with complementary messages using a variety of delivery mechanisms (e.g., teaching sessions in school, billboards, and radio or television chat shows), has a higher "dosage" than another program that uses fewer and less-intensive approaches.
One practical, intuitive and less computationally intensive approach is via traffic control policies, which are discussed in the following exposition.
Array CGH offers the potential for high throughput and high-resolution genome analysis and is a less labor intensive approach than other molecular cytogenetic analyses.
We don't yet know if less intensive lifestyle approaches would influence genes as this program did.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com