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We hypothesized that a less frequent schedule at hemodialysis therapy initiation is associated with greater preservation of RKF without compromising survival among patients with substantial RKF.
Stories were still being acquired for the magazine by Street & Smith in November, and since the final issue would have appeared on newsstands some time in September, this implies that the magazine went on hiatus (possibly because of the printers' strike) with the expectation of returning, perhaps on a less frequent schedule.
Unless the participant declines, the interventionist will continue to contact the participant on a progressively less frequent schedule, starting monthly and decreasing to semi-annually to remind her/him of the opportunity to re-enter BE WELL.
However, in the US, Epoetin alfa is commonly administered weekly in the oncology setting [ 5]; similarly, a less frequent schedule (once every two weeks) for darbepoetin alfa administration has been routinely adopted [ 8].
Ultimately, a lower dose and less frequent schedule (for example, twice per day) of this oral angiogenesis inhibitor was adopted for the randomized study in front-line metastatic colorectal carcinoma comparing FOLFOX combined with PTK787 to FOLFOX alone, mirroring the successful design for bevacizumab approval in colorectal cancer [15].
Unless the participant declines, the interventionist will continue to contact the participant on a progressively less frequent schedule, starting monthly and decreasing to semi-annually to remind her/him of the opportunity to re-enter E-LITE and to maintain contact for possible recruitment for the final assessment at the end of E-LITE.
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Controlled studies of this agent at higher doses and less frequent schedules of administration are ongoing.
In both preclinical and clinical investigations, temozolomide has demonstrated markedly schedule-dependent anticancer activity, with more frequent treatment schedules generally producing greater cytotoxicity than less frequent schedules (Stevens et al, 1987).
Early preclinical and clinical studies revealed temozolomide to have significant schedule-dependent anti-tumour activity, with more frequent dosing schedules producing greater cytotoxicity than less frequent schedules (Stevens et al, 1987; Newlands et al, 1997).
The most striking response from the survey of 65 large companies whose employees travel frequently, Mr. Mitchell said, was a willingness to accept less-frequent scheduling -- a kind of flight rationing -- in return for more dependable service.
Its less frequent publishing schedule dictated the use of less topical cover subjects that would not quickly become stale on newsstands.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com