The findings in these kindreds were consistent with the observations made in less familial or general samples of schizophrenia or bipolar patients [1] [4] and their non-affected relatives [1], [5], [26] [28].
I told my father — using other, less familial language — we don't flush animals down the toilet.
Upon cell reprogramming of somatic skin cells (fibroblasts) into induced pluripotent stem cells (iPSC), we generated DAn from patients with sporadic PD (sPD) (90‐95% of cases) and patients with a less frequent familial form caused by mutations in the gene LRRK2 (LRRK2.
6 In French pediatric patients, the prevalence of pediatric MMD/MMS was approximately 1/20 of that estimated in Asia, with a less frequent familial history, around 7.5%.
"People feel very familial with them, and get very comfortable with them.
The number of mutations required appears to be less in familial breast cancer compared to sporadic breast cancer.
A further proportion of cases arise in the presence of a less striking family history, with later average age at onset and lower penetrance: familial breast cancer.
Overall, informed responders recognised both their familial and personal DM risk; most discussed diabetes with their family (69%), though less so with friends (42%); however, 44% of them still did not consider themselves to be at risk.
In humans, NaV1.2 mutations are associated with inherited epilepsy, mainly benign familial neonatal-infantile seizures (Heron et al., 2002) and less frequently with other forms of epilepsy such as generalized epilepsy with febrile seizures plus (Sugawara et al., 2001).
Altogether, these data emphasize a less deterministic model with a role for familial and other environmental factors operating at different developmental time periods.
