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In particular, MT-targeting bivalent compounds (MTBCs) represent a promising class of molecules; however, surprisingly, the majority of MTBCs reported so far exhibit equal if not less efficacy than their building monomers.
According to our model, N-terminally truncated PrP binds Dpl with less efficacy than full length PrP, even if over expressed.
Indeed, sequential treatment of MM cells with MS275 followed by Len shows less efficacy than simultaneous treatment with this combination.
These drugs reduce blood pressure and protect against cardiovascular outcomes such as myocardial infarction and atrial fibrillation although with slightly less efficacy than angiotensin converting enzyme inhibitors.
36 Likewise, although extensive specific information is not available, clinical studies do not support that ICS in older adults have less efficacy than in younger ages.
The Ulster strain is known to trigger immunity in the vaccinated chickens with less efficacy than strain Hitchner B1 when given as aerosol vaccine.
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We were particularly interested in applying this approach to bortezomib, a therapy that has shown less efficacy in solid tumors than in non-solid tumors such as multiple myeloma, perhaps because of resistance mechanisms seen only in 3D.
As expected, NSC11668 showed less efficacy against wild-type yeast than against the ABC16-Monster strain, highlighting the strength of the ABC16-Monster technique as a tool for identifying novel molecules and targets.
In an in vivo partial lung resection model, Quixil showed significantly less sealing efficacy than fibrin sealants utilizing aprotinin.
Co-application of Group A compounds with carboxin (a complex II inhibitor) showed less antifungal efficacy than when co-applied with AntA (Table 3).
The parameters we studied have less clinical efficacy than the classic methods of TT, as recent studies of the literature demonstrate.
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CEO of Professional Science Editing for Scientists @ prosciediting.com