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However, age does not seem to be associated with more toxicity or less efficacy.
ATP has had less efficacy for faster VTs 41-799%) and have higher probability of accelerating tachycardia (5-55%).
As expected, NSC11668 showed less efficacy against wild-type yeast than against the ABC16-Monster strain, highlighting the strength of the ABC16-Monster technique as a tool for identifying novel molecules and targets.
Mean response rate was 55% with greatest efficacy in trigeminal (75%) and occipital neuralgia (100%) and less efficacy in trigeminal neuropathic pain (50%) and persistent idiopathic facial pain (20%).
The use of nanosuspension for intravenous delivery resulted in considerably less efficacy with TGI being 42%. Figure 6 Plots of mean tumor volume versus time in xenograft mice for intravenous paclitaxel.
In particular, MT-targeting bivalent compounds (MTBCs) represent a promising class of molecules; however, surprisingly, the majority of MTBCs reported so far exhibit equal if not less efficacy than their building monomers.
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Of those, few have ever been reviewed by the F.D.A. for safety, much less for efficacy.
So it is no surprise that alternative medicine, which offers valuable support and sympathy along with treatments of less obvious efficacy, is big business.
In the wake of such recent citizen-mediated news events as the Asian tsunami, Hurricane Katrina, the London tube bombings, senator George Allen's political suicide, the Virginia Tech massacre, et al, the real question is why anyone would still wonder about the possibility, much less the efficacy, of so-called citizen journalism.
However, there is also a tendency for a more precisely targeted agent to have a less overall efficacy.
Later, we need less immunosuppressive efficacy, to avoid risk factors for chronic toxicity, cardiovascular disease, and malignancy.
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