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The proportion of patients treated at the MTD declines as more patients opt for a higher dose, and the proportion of patients treated at doses lower than the MTD, that is, at less efficacious doses, also declines.
Only the lower, less-efficacious dose was compared to aromatase inhibitors and found to have similar efficacy; so far, no data directly comparing fulvestrant HD with an aromatase inhibitor exist.
However, a large proportion continued to receive the less efficacious single-dose Nevirapine regimen [ 35].
We investigate this issue in terms of achieving twice the coverage with a less efficacious 1-dose vaccine but with a shorter delay to full seroconversion.
These are not only believed to be associated with minimal risk of toxicity but are also expected to be less efficacious than the higher doses that may be used later in the trial.
The low doses (125 mg/kg diet) were less efficacious and did not affect tumor morphology.
2 Recent studies have shown that raltegravir is less efficacious in achieving and maintaining viral suppression when dosed once daily.
Low doses of either agent were less efficacious and did not significantly increase apoptotic cells (Table 2).
PM5S was able to transactivate FXR in a reporter assay in a dose-dependent manner, but was less efficacious than CDCA (Fig. 4C), generating an EC50 of >83 μM, compared to 4.6 μM for CDCA.
The low doses of DHEA and DHEA 8354 were less efficacious.
The research question is: Is the current recommended dose of AL for the treatment of uncomplicated malaria less efficacious in the children with severe acute malnutrition (SAM children) compared to the non-SAM children and is PK in cause?
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CEO of Professional Science Editing for Scientists @ prosciediting.com