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This is consistent with a common perception that it is less difficult to identify broadly binding compounds with low affinity than it is to find broadly binding ones with high affinity.
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Hypoactive delirium may be eight times more common (61%) than delirium associated with agitation (8%) [ 39], but, while no less important, hypoactive delirium is difficult to identify without active screening.
Peritoneal deposits may be outlined by ascites and are best seen on delayed contrast-enhanced images, but deposits of less than 1 cm may be difficult to identify on any imaging modality [42].
Earlier blood tests and a DNA test were far less predictive, and celiac disease has been difficult to identify, especially because its symptoms vary widely.
Meanwhile, it would have been difficult to identify the other less significant channel domains (i.e., Voltage_CLC, Form_Nir_tranp and ECF-ribofla_trS) via their original HMMER2 E-values since these values can span between a much less significant range of between 3.54e 3 and 3.89e 1 as compared to the very significant E-values of MIP at 1.46e 127.
Compared to behaviour change, less is known about behaviour maintenance, making it difficult to identify effective working mechanisms from literature.
Influenza cases do present with mild or asymptomatic infection, but these cases will be difficult to identify in a surveillance program and are less severe in clinical outcome.
For instance, if the less healthy individuals are more likely to purchase health insurance, it may be difficult to identify the health insurance effect without carefully controlling for the health conditions of an individual.
It is sometimes difficult to identify with certainty mild to moderate disability in children less than two years old.
To be clear, although bilateral compensations in rodents are often more difficult to identify than unilateral compensations, bilateral compensations should not be considered less significant in magnitude.
When species are hard to observe, difficult to identify and distinguish, or attract little attention, local informants may be less aware.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com