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In poorly differentiated tumors with less differentiation (less K10 positivity), high levels of CTIP2 was observed which did not express K10.
Hepatocellular carcinoma with NIN was better tissue for investigating the dedifferentiation and progression of HCC because the inner nodule of less differentiation developed sequentially from the well-differentiated outer nodule with the same genetic background (Kojiro, 1998; Midorikawa et al, 2002).
In this study, we showed that NRP2 expression correlates with less differentiation in HCC patients as well as with a de-differentiated, mesenchymal-like phenotype of HCC cell lines (Fig. 1).
The previous studies have demonstrated that CCA with less differentiation shows a poorer outcome and high incidence of metastases than well differentiated tumours (Nakajima et al, 1988; Nakanuma et al, 2000).
There's less differentiation with suits too.
I support less differentiation and more collective action by investors.
This may lead to less differentiation between organizations, and a shifting composition of activities within the organization.
As one of his friends put it, "The problem with shooting from an airplane is that there is less differentiation in point of view.
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Compared to other scombroid species with cosmopolitan distributions, we found substantially less genetic differentiation between Atlantic and Pacific sub-populations of yellowfin tuna and no inter-oceanic genetic differentiation of skipjack tuna.
Isolated cells exhibited less significant differentiation than paired or aggregated cells.
The tracts of reptiles generally show less regional differentiation than do those of birds.
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