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As relatively less developmental efforts are required for commercializing new combinations, there is scope for developing retinoid based combination therapies for improved treatment of aging.
Lower inter-rater reliability is documented for the <2 years age band (κ=0.55), as younger children's gross motor abilities are more variable, and less developmental information is available on which to base the classification.
Compared with placebo, both antenatal dexamethasone and betamethasone were associated with less developmental delay in childhood (Relative Risk (RR) 0.49, 95% Confidence Interval (CI) 0.24 to 1.00, 2 trials, 518 children), and a trend towards fewer children having cerebral palsy (RR 0.60, 95% CI 0.34 to 1.03, 5 trials, 904 children) [ 3].
If genuinely involving 'country-ownership' in criteria definition [ 55] such measures can allow for a better assessment of aid effectiveness and avoid problems of fungibility, where donor funding allows diversion of public revenues into other forms of spending of less developmental value.
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Indeed, the complete knockout of the dcl1 mutant is embryo-lethal, with partial loss-of-function dcl1 mutants demonstrating less severe developmental defects [68].
We chose to utilize inhV because it caused less overall developmental defects compared to other PDGFR inhibitors such as AG1295.
Other, less frequent, developmental defects were exencephaly and spina bifida.
More common is a milder clinical picture, without generalised epilepsy and with less severe developmental delay, referred to as intermediate DEND.
In contrast, less severe developmental defects are observed upon targeted disruption of NFκB family members that display more limited tissue expression.
As ponds in this region become increasingly ephemeral [ 28], resident amphibians may be forced to adopt ever more rapid and potentially less fecund developmental profiles.
Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations.
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