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When the targeting ligand was attached to shorter PEG chains that were shielded by a PEG overbrush layer (buried-ligand architecture), significantly less complement activation was observed when compared to the more traditional exposed-ligand motif.
A retrospective comparison of complement activation using different techniques suggested that less complement activation is seen using centrifugal methods [ 3].
GTKO/CD55-CD59-HT NICC triggered significantly less complement activation than WT NICC, and generated significantly less thrombin than WT NICC, as demonstrated by reduced endogenous thrombin potential.
The lower sieving coefficient observed when citrate was used, may then argue in favour of less complement activation in the filter and thus improved biocompatibility.
We therefore hypothesized that regional anticoagulation with citrate causes less complement activation, polymorphonuclear cell degranulation and endothelial MPO release as compared to heparin, during CVVH in critically ill patients with AKI.
These genetically modified (GM) NICC were less susceptible to humoral injury in vitro than WT NICC, inducing significantly less complement activation and thrombin generation when incubated with baboon platelet-poor plasma.
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Sialic acid-independent strains, that presumably are able to bind to CR1 via a native ligand, showed less complement-dependent enhancement of RBC invasion than sialic acid-dependent strains that do not utilize native CR1 ligands.
Unlike type I antibodies, type II antibodies do not translocate CD20 into raft microdomains and display less complement-dependent cytotoxicity than type I antibodies.
It has been a significantly less interesting complement to the men's game since Henin shocked the sport by announcing her retirement in May of last year.
Women's tennis has been a significantly less interesting complement to the men's game since Justine Henin shocked the sport by announcing her retirement in May 2008.
Cockles, or the newly available and also briny mahoganies, which cook in less time, complement Asian seasonings of lemon grass, garlic, chilis, ginger and lime.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com