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Accelerated approval is a way to get drugs to the sickest patients more quickly, with less clinical data.
But it also means therapies are approved with less clinical data under their belt, and that was the case with Avastin.
Being relatively new, cobicistat has less clinical data available.
On the other hand there is less clinical data exciting concerning this novel antibiotic substance associated with safety questions [ 41].
While there is much less clinical data, most of the more rare mutations, KIT exons 13 and 17, and PDGFRα exons 12 and 14, are sensitive to imatinib in vitro [ 9].
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First, these contradictory findings could be explained by the less-informative clinical data, especially lack of the definition of "healthy" control subjects.
In cardiac surgery, administrative data are less suitable than clinical data for the purpose of benchmarking.
Hence the cost-effectiveness estimates are inevitably less precise than the clinical data on which they are based.
Although numerous PK/PD data from various in vitro and in vivo experimental studies favor the use of continuous infusion, the current clinical data are less convincing and insufficient to instigate a global shift from conventional bolus dosing.
Clinical data are less documented.
However, there is much less certainty on how this clinical data should be collected, maintained, disclosed, and used.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com