Since loop LE contributes two out of four residues (LE1 and LE2) for the Ar/R selectivity filter, we speculate that the unwinding character may help in regulating the channel transport in orthodox AQPs that lack the intra-helical salt-bridge interaction.
LE contributed to study design.
LE contributed to the discussion of the manuscript, performed western immunoblot, ROS and cell viability assays.
LE contributed to data analysis, interpretation of results and critical revision of the manuscript.
LE contributed to the design of the study, interpretation of results and writing of the manuscript.
LE contributed to the statistical analysis and interpretation of the results.
NEM and LE contributed to the conception, design, acquisition and analysis of data and wrote the manuscript.
LE contributed to study design, drafting and revising the paper and participated in data collection and analysis.
DA wrote the first draft of the manuscript, LE contributed to manuscript development, and all authors read and approved the final version.
LE contributed to the design and implementation of the study, to the interpretation of data, and to the writing and completion of the manuscript.
