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The cataracts of the Dbl transgenic mice were characterized by a dramatic fibroblastic dysplasia of the lens, disruption of the lens architecture and aberrant epithelial cell proliferation.
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As therapy moves towards treatment of patients at a younger age, the advantage of avoiding potential contact with the crystalline lens or disruption of the hyaloid face may result in this being a much safer and preferred method of delivery.
Despite the limitations of the study, to the best of our knowledge, this is the first report of SEM finding of anterior lens capsule disruption in a phacolytic glaucoma patient, and this finding may be helpful to better understand the mechanism underlying phacolytic glaucoma and lens particle glaucoma.
Here, we report a case of phacolytic glaucoma with anterior lens capsule disruptions visualized by scanning electron microscopy (SEM).
Here, we present a case of phacolytic glaucoma in which anterior lens capsule disruptions were identified by SEM and that was successfully treated.
The objectives of the current report were to characterize gross morphology of young (5 wk) and old (54 wk) mouse lenses with targeted disruption of both the alphaA and alphaB genes, in comparison to age matched wild type lenses, using scanning electron microscopy (SEM) and confocal microscopy, to elucidate the possible functions of alpha-crystallin in the lens.
Wu et al. found that TiO2 nanoparticle could efficiently inhibit the cell proliferation in human lens epithelial cells via disruption of calcium homeostasis of elevating intracellular Ca2+ and inhibiting Ca2+ ATPase activities [51].
Mice carrying the Dbl cDNA linked to the mouse metallothionein promoter express the Dbl protein in the lenses and show dominant bilateral lens cataracts characterized by disruption of the lens architecture, aberrant epithelial cell proliferation and a dramatic fibroblastic dysplasia [11].
Unexpectedly, all Nbn-deficient lenses develop cataracts at an early age due to altered lens fibre cell differentiation, including disruption of normal lens epithelial and fibre cell architecture and incomplete denucleation of fibre cells, and these changes are independent of the p53 pathway.
Transgenic mice, on the other hand, showed disruption of the lens architecture and epithelial cells exhibited a disorganized proliferation.
Risk factors for the development of endophthalmitis include metal rather than glass or blunt trauma injuries, retained intra-ocular foreign bodies, disruption of the lens, and delay in primary repair of >24 h.
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