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Lens development (see Piatigorsky, 1981) is a key event during eye organogenesis, and abnormal lens development results in a range of lens structural abnormalities and cataract formation (see Box 1).
A protein forms granules with RNA to control gene expression and mammalian eye lens development.
Crystallins have been shown to not only function as structural proteins but also involve in lens development (Andley, 2007).
Fig. 5 Transcription factors that are used for lens development and activation of crystallin promoters in different species.
These mice may provide useful animal model for elucidating the mechanisms of lens development, and etiology of microphthalmia.
This interaction supports the dual roles of filensin in the lens; roles that could be important during lens development.
This paper briefly examines the Fresnel lens development since 1970s and investigates the losses inherent in the linear Fresnel lenses.
The expression of transcription factors, Pax6, Hsf1, and Hsf4b known to be involved in lens development is down regulated in the lens of these Tg mice.
Overall, this study has allowed us to revisit some of the mechanisms involved in early lens development, has provided us with insights into the fate of cells during this rapid phase of murine lens growth, and has provided a novel method to study the rate of new fiber cell differentiation over a defined period of lens development and growth.
Haploinsufficiency of Pax6 results in perturbed lens development and homeostasis.
Ueda et al. indicates that α-B and γS-crystallins increases upon early postnatal lens development.
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