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Given that current synopses have used a large amount of evidence from candidate gene studies, most have considered for grading all probed associations that pass very lenient levels of statistical significance in meta-analysis (typically, P < 0.05 inferred from random-effects calculations).
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The horizontal dashed line represents the statistical-significance level where p = 0.01 (an uncorrected lenient level, used to error on the side of inclusion).
Interestingly, many of the effects of these genome-wide significant variants at the lenient level involved decreased GM volumes, including the medial, middle and inferior fontal gyri.
Similarly, performing additional rounds of selection (be it very stringent, normal, or lenient) also does not substantially change the observed noise levels of the selected promoters.
Our lenient definitions of substance use (i.e., fairly low levels of the considered risk behaviors) may reflect experimentation more than sustained substance use in some cases, and may be regarded as a normal aspect of adolescent development in some instances [ 6- 8].
In this study, low levels of parental efficacy in reducing teen tobacco use and lenient household rules about smoking in the home was also reported, despite parents often providing contradictory anti-smoking verbal messages.
Since the absence of the white noise was the main difference between this experiment and Experiment 3, it is likely that the increased signal-to-noise ratio resulted in higher levels of confidence, leading to no adoption of a more lenient response strategy in the high-load conditions here.
When it comes to employees with different levels of education, and their attitudes, we find that employees with low education are more lenient towards sick leave and are more stressed than those with higher education.
However, since our objective was to assess the potency of the programme to improve guideline adherence and adherence determinants, we preferred this more lenient alpha level in the spirit of discovery.
Due to the large number of SNPs tested simultaneously in GWAS, the usual statistical level of 0.05 is too lenient and will result in thousands of false positive results.
These findings may also explain why recent graduates were more lenient than students in setting the required level of anatomical knowledge for beginning clerks [ 14].
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