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What is not unusual, unfortunately, is the lengthy timeframe of this regulatory trajectory in the context of FDA action.
Since phase III definitive efficacy trials with cancer endpoints require a lengthy timeframe and considerable resources for completion, it is critical to first optimize agent delivery and trial design and to determine preliminary efficacy via the conduct of phase II trials.
Should the entire west Antarctic ice sheet collapse, sea levels would balloon by around 3.5m, albeit over a lengthy timeframe.
This lengthy timeframe concerned many and there were increasing concerns that any meaningful decision would be too hard for the government to make.
Using neurodegenerative disease as an example, Jesus emphasised the lengthy timeframes, significant costs and discouragingly high attrition rates associated with drug development.
When the damage to forests as a result of a disaster is severe, the negative impacts can be long-lasting because of the lengthy timeframes generally involved in forest recovery.
"This gives a long enough timeframe to claw back any losses from volatile periods".
Please, will you set a reasonable timeframe to stop selling eggs from caged hens?
Unfortunately, I don't have an update or timeframe to share at this point in time.
Create a timeframe to finish the entire project.
This way you can concentrate your efforts and set a realistic timeframe to achieve them.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com