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Mean telomeric lengths were calculated using ImageQuant software (Molecular Dynamics, Sunnyvale, CA, USA) based on center of mass calculations and expressed in kb ± SE.
The mean stream lengths were calculated using the formula of total stream length of order divided by total number of stream segments of order.
Branch lengths were calculated using the average pathway method [77].
Fragment lengths were calculated using GeneMapper 4.0 (Applied Biosystems) software.
These branch lengths were calculated using the GTR + I + G ML model of evolution in PAUP 4.0.
Gestational lengths were calculated using prenatal scan data or last menstrual period dates if scan data were not available.
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The median of all the tip-to-root branch lengths was calculated using ape and LAGOPUS package in R project [ 39].
Of the remaining 56,000 trees (28,000 from each of the parallel runs) a majority rule consensus tree with average branch lengths was calculated using the sumt option of MrBayes.
However, height and crown length were calculated using the locally developed parameters from (Seifert et al. [2011]).
Neurites were traced (Fig. S2A1) and numbers of branching points and neurites extending from cell body (primary neurites), length of the total traced neurites (total neurite length), and maximum neurite length were calculated using HCA-Vision software (CSIRO NSWW, Australia).
Gene length (l) and protein length were calculated using Ensembl v.75 (Flicek et al. 2013).
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