Suggestions(1)
Exact(1)
(Meanwhile, calorie restriction another popular way of lengthening mouse lifespans can make them live up to 40% longer).
Similar(59)
A single mutation in a gene can lengthen a mouse's life by nearly a third without any noticeable harm, according to a study in today's Nature.
Telomeres were also longer in MEFs from Slx4−/− mice, but lengthening was reversed by expression of mouse SLX4 in these cells so that telomeres were similar in length to wild-type MEFs.
The slight lifespan lengthening of SJL/J mice under chronic irradiation that we observed in our last study could be explained by an adaptive response to radiation able to induce extended tumor latency as it has been described by Mitchel et al. (Mitchel et al. 1999; Mitchel et al. 2003; Mitchel et al. 2008).
It has been observed that global 3'-UTR shortening by APA can activate oncogenes in cancer cells [ 4], whereas 3'-UTR lengthening can occur during mouse embryonic development and differentiation [ 5, 6].
We recently reported that 3'UTRs progressively lengthen via APA during mouse embryonic development [18] and this regulation coordinates with various aspects of development including proliferation, differentiation, and morphogenesis, and likely results from weakening of the general mRNA polyadenylation activity when cells are committed to specific types.
Interleukin-2-loaded polymeric nanoparticle inhibited the tumor growth and can lengthen survival in mice B16F1-bearing melanoma.
(E – G ) Addition of Meth to the drinking water of C57BL/6 mice lengthens the night-time activity bouts in a concentration-dependent manner.
The clear influence of p53 on mouse longevity, either lengthening or shortening it, led Helfand and colleagues to investigate the role of the Drosophila p53 homologue, Dmp53, in longevity [ 17].
When the researchers tested the effects of lengthening the window in which mice were allowed to feed on high-fat food, those maintained on a regimen of nine-hour feeding and 15-hour fasting gained the least weight.
It appears that not all of the telomere-related functions of the SLX4 complex require stable association with telomeres, because telomeres are longer and more fragile in organs and cells from Slx4−/− mice and telomere lengthening in Slx4−/− MEFs can be reversed by expression of wild-type SLX4.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com