Although there is a trend to period lengthening upon miRNA loss, this effect is statistically not significant (p=0.197; student's t test).
Running wheel analysis in DD of Meth-infused Bmal1 −/− animals demonstrated a significant ultradian period lengthening upon drug infusion suggesting that rhythmic uptake is not required for Meth to exert its period lengthening effect, in line with a previous study performed in rats (Honma et al., 1987).
In cells, this membrane deforming activity generates small buds, which can lengthen into extensive protrusions upon actin cytoskeleton polymerization.
Were such a proposal acted upon, it would lengthen the period in which graduates have to make repayments, possibly extending it to cover the rest of their careers and introducing the concept of a career-long "graduate tax" to the UK.
Whereas stalks remain short (1 µm) in nutrient-rich conditions, they lengthen dramatically (up to 30 µm) upon phosphate starvation.
Thus, cell lengthening or shortening upon partial knockdown of a candidate motor provides a way to discriminate the alternative models shown in Figure 1.
A decrease in the rate of shuttling was observed upon lengthening the alkyl chain of 63 as compared to 62, the magnitude of which corresponds to an increase in activation barrier of ca. 5 kJ mol 1.
In Chlamydomonas, mutants with abnormal flagella lengthening display defects upon flagella regeneration (Tam et al., 2007), whereas in vertebrates, both Broad-minded and Nde1 knockdowns, which also cause abnormal lengthening of primary cilia, impact on cell cycle progression (Kim et al., 2011) and sonic hedgehog signaling (Ko et al., 2010).
These results suggested that the rate reduction arises predominantly from local mispositioning of the general base upon lengthening its side chain by one methylene group and allowed us to use the D38E mutation in double-mutant systems to probe the effects of other mutations on general base positioning.
Upon repeated deformation cycles, the fibers persistently lengthen, leading to a lower stiffness at the same strain and hence a softening effect (Münster et al. 2013).
