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Loci with higher length repeats provided an advantage of accurate allele calling due to their larger allele size difference.
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As the length of the repeat increases, the growing hairpin structure gains thermodynamic stability, with repeat length providing an important positively correlated diagnostic for disease severity.
This information, in conjunction with the purity of the repeat region encoding the poly-Q tract and the lack of conservation of repeat length, provide indicators for the propensity for polymorphic variation in the full repertoire of poly-Q encoding genes.
If it isn't the right length, repeat steps 1-3.
Thus, variation in the length of the AR (CAG n repeats may provide insights into the underlying genetic etiology and further development of PCOS.
We also generated large fragment libraries of 6, 8 and 12 kb nominal fragment lengths, to provide linkage information across repeat structures.
Our pilot experiment with various probe lengths of repeat junction sequences on NimbleGen array suggested that probes with a 52-bp length provides the best performance in the mapping data (data not shown).
A longer FFT length provides a more accurate frequency resolution and limits the increase in computation time due to repeated FFT processing, but results in an increased memory requirement.
Congress provided repeated relief.
The standard deviation and standard error of all observed tandem repeat array length alleles is also provided, which provides an indication of the spread of allele sizes.
A room-length mirror provides the illusion of greater space.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com