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The results of this structural annotation indicate that all CSEPs had comparatively low values for mean lengths, mean proportion disorder, mean maximum length of disorder, mean model quality and mean number of domains (Additional file 16).
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If this interpretation is correct then the small length scale of disorder suggests that cellulase interactions with fibril surfaces may not be fully specific towards particular conformational states.
In addition, relevant clinical variables (family and personal medical and psychiatric history, length of the disorder, main symptoms and medical comorbidity) will be also assessed.
Thus, altered half-life due to divergence in the length of terminal disorder could have a significant impact on the duration for which a protein can impart its function in a cell and thus affect cellular behavior.
More precisely, (1) paralogous proteins with similar length of terminal disorder tend to have similar half-life values (median difference in half-life is close to zero; Figure 4B, bottom boxplot; Table S6A), and (2) the half-life of proteins with longer N-terminal disordered regions tends to be 14 min shorter (median) than that of their paralogous partners.
We specifically asked whether paralogs diverged in the length of N-terminal disorder or in the number of internal disordered segments (but are otherwise largely similar) and, if they did, whether this corresponded to changes in their half-life.
(5) Here κ is the correlation length of the quenched disorder.
Differences were noted namely length of stay, communication disorder, and type of stroke (e.g., ischemic).
DIS _ avg The average length of the predicted disorder segments divided by the sequence length (1 feature).
DIS _ max The maximal length of the predicted disorder segment divided by the sequence length (1 feature).
Lung et al. [ 6] also conclude that the average telomere length of major depressive disorder patients was significantly shorter than that of their community controls.
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