Exact(2)
The molecular identities of these critical species have yet to be determined in different lipidomes despite emerging evidence that differences in carbon chain length, linkage, and phosphorylation status fundamentally alter biological activity [ 1, 15– 15].
Each lipid class contains hundreds of different lipid species, further varying in fatty acid chain length, linkage, and saturation, among others (Coskun and Simons, 2011), the exact measurement of which has been empowered by the advent of lipidomics (Shevchenko and Simons, 2010; Wenk, 2005).
Similar(58)
At first release, we did not include the PI family or their bioactive PIPx metabolites given the significant challenges associated with automating the visualization of all theoretically possible combinations of sn-1 and sn-2 carbon chain lengths, linkages, and variations in phosphorylation of the phosphoinositol head group.
The length of linkage groups varied from 121.5 cM for linkage group 10 (C10) to 278.7 cM for linkage group 9 (C9).
Restriction fragment length polymorphism linkage map for Arabidopsis lhaliana.
Polyubiquitin is a diverse signal both in terms of chain length and linkage type.
It is not an ideal method: since it relies on the length of linkage disequilibrium on one haplotype in relation to the frequency of that haplotype, it may be vulnerable to different sampling strategies that could alter the apparent frequency of that haplotype.10 Allele-specific recombination rates could also produce a similar effect.
How is the length and linkage specificity of ubiquitin chains controlled on endogenous substrates in vivo ?
Ubiquitin has seven lysines, creating opportunities for chain length and linkage diversity.
A chi-square test was performed for each base length and linkage group combination independently (results not shown).
A possible explanation for this discrepancy may involve number, length and linkage type of ubiquitin chains, aside from molecular context.
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