People are constantly being kicked out of hospitals early, or not admitted at all, particularly in the United States, thanks to insurance companies refusing to cover reasonable-length, evidence-based, psychiatric treatments.
We studied the length of evidence texts: as mentioned in the BioCreative guidelines (19), the evidence texts for GOA may be derived from a single sentence, or multiple continuous, or discontinuous, sentences.
The results allow to estimate the effective anchorage length and evidence that the debonding occurs at the fibers/matrix interface after a considerable fibers/matrix slip.
The distribution of syntenically retained classical maize genes between the two subgenomes of maize roughly mirrors that of all syntenically retained genes supported by full length cDNA evidence.
To develop a subset of genes comparable to our classical gene list we adopted an approach used previously [18] restricting ourselves to the subset of annotated maize genes supported by sequenced full length cDNA evidence (see Methods) [19], [20].
Given the bias towards greater expression of maize1 homeologs, the slight bias towards higher numbers of maize1 genes with retained homeologs among genes supported by full length cDNA evidence was expected, but this finding is not of significant interest.
Here we show that the genes of interest to maize geneticists are much more likely to be syntenically conserved across all grasses than the average gene supported by full length cDNA evidence.
Figure 4 plots these data for all 34,579 genes supported by full length cDNA evidence, the 468 genes of the classical gene list, and the subset of 102 genes on the classical gene list identified by mutant phenotype prior to cloning.
Using the online syntenic analysis tool SynMap [21], we found that, compared to the average maize gene supported by full length cDNA evidence, classical maize genes, including those with known mutant phenotypes, are much more likely to possess conserved homologs at orthologous syntenic locations – true orthologs, in Japonica rice, sorghum, and brachypodium (Figure 3).
The strong consistency of these three measures, as well as IG and S, with motif length, provides evidence that they can successfully discriminate motifs of different lengths.
Contigs were allocated to OM homoeologs as described above and performance was evaluated using criteria such as %ID to OM, number of matched homoeologs in OM, contig length, and evidence for inter-homoeolog mis-assembly.
