Sentence examples for led to the sequestration of from inspiring English sources

The extravagant lifestyles of the fifth and sixth lairds led to the sequestration of the estate, which was sold off piecemeal to pay their debts.

An EHD2 mutant expressed in myoblasts led to the sequestration of myoferlin in recycling endosomes and inhibition of myoblast fusion [37].

Not only tri-methylation, but apparently mono- and di-methylation as well, deposited by the sequential action of two histone methyl transferases (HMT) called MET-2 and SET-25, led to the sequestration of the modified chromatin at the nuclear envelope [ 3].

Restored engineering leads to the sequestration of soil organic carbon (SOC), including labile and refractory fractions in the soils of the degraded lands.

In particular, the presence of a catalytically inactive form of Atg4B, mStrawberry-Atg4BC74A, was shown to lead to the sequestration of EGFP-LC3 in the cytoplasm and depletion from the nucleus [25].

The production of E1A mRNA within hepatocytes that contains multiple microRNA binding sites could lead to the sequestration of mir122 away from its endogenous mRNA targets or depletion of the total mir122 content in the cell.

For example, MYC has been shown to directly induce transcription of Cyclin D2 and Cdk4, which in turn leads to the sequestration of p27 away from Cyclin E and thus the accumulation of Cyclin E/Cdk2 complexes; these kinases then lead to the phosphorylation and inactivation of RB and its family members p107 and p130 [21], [22], [22].

This leads to the sequestration of these transcription factors from their usual promoter binding sites [ 78].

In human cells, CR serum-mediated induction of SIRT1 leads to the sequestration of proapoptotic factors and consequent promotion of cell survival [ 38].

SIR complex association also leads to the sequestration of the silent chromatin at the NE through association with Esc1 (Gartenberg et al, 2004; Taddei et al, 2004).

Phosphorylation by the insulin-activated protein kinases Akt and SGK at three conserved sites on FoxO factors leads to the sequestration of FoxO in the cytoplasm, thereby preventing FoxO factors from transactivating their target genes [ 18, 39- 42].