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Reductive amination of the ketone 11 with primary amines and NaBH OAc 3 led to the secondary amines 6a d, cis-6h and trans-6i.
Han, et al. found that immuno-stimuli led to the early induction of several genes, including cytokines, which subsequently led to the secondary induction of gene expression.
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However, doping is always complex and could lead to the secondary phase formation [14].
Furthermore, acid recovery after hydrolysis leads to the secondary treatment process (Mosier et al. 2005; Kumar et al. 2009).
Importantly, the widespread deregulation of many of these pathways in human cancer leads to the secondary inactivation of Hippo signaling, ultimately contributing to tumorigenesis (reviewed by Yu and Guan [42] and reviewed by Irvine [33]).
Scavenging leads to the secondary poisoning of thousands of innocent companion animals and unoffending wildlife, including threatened and endangered species, each year.
Independent information (from other molecular markers, morphology and ecological traits) is subsequently added to lead to the secondary species hypothesis (SSH) [ 55].
The high severity of the acid catalysed reaction is sufficient to hydrolyse the majority of the hemicellulose fraction, but unfortunately also leads to the secondary production of inhibitor byproducts.
Similar to oral infection, experimental intracerebral scrapie inoculation also leads to the secondary lymphoid organs rapidly accumulating infectivity and misfolded prion proteins (Fraser and Dickinson 1970; Hunter et al 1972).
Initially, studies focused on the hypothesis that IPF, as a result of scarring or other proliferative mechanisms, could lead to the secondary development of lung cancer (Samet, 2000; Ma et al, 2001).
At approximate 3 4 Ma, the Zagros orogeny began impacting the Azadegan zone (margin area of the Zagros foreland basin) and led to the drastic secondary deformation of the paleo-trap.
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