Sentence examples for led to substantial increases from inspiring English sources
Despite limits imposed by antitrust regulators, the merger between Guinness and Grand Metropolitan to create the food and drink giant Diageo led to substantial increases in the price of Scotch.
Over time this migration to the suburbs, along with rising local populations, led to substantial increases in the geographic extent, or spatial footprint, of metropolitan areas in the United States.
The new regulations were put into effect on March 1st, 2004 and led to substantial increases in minimum wages.
Setting fishing mortality to the maximum sustainable yield led to substantial increases in biomass (+100%) and catch (+33%) at the EEC scale.
The radiation induced defects led to substantial increases in the IFSS, and only a marginal decrease is observed in the measured fracture strength.
Recent progress in increasing intracellular supplies of polyketide building blocks combined with the development of stable high copy number vectors has led to substantial increases in S. coelicolor polyketide titers.
Polarization of Cr, on which a steady state film had been formed, to positive and negative potentials led to substantial increase of the conductivity of the film.
In contrast, triple mutations in Rb, p107 and p130, led to substantial increase in myoblast death and to elongated bi-nuclear myocytes, which seem to derive from nuclear duplication, as opposed to cell fusion.
As shown in Figure 5C, addition of the ectosomes indeed led to substantial increase in HAP2-HA.
Importantly, both ADP and ATPγS binding led to substantial increase in HX protection compared to nucleotide-free ClpB oligomers, including Walker A motif regions.
These authors found that PET information, co-registered with treatment planning computed tomography (CT), led to substantial increase or decrease in the estimated gross tumor volume (GTV) in 6 of 34 patients.
