Sentence examples for led to profound modifications from inspiring English sources

There, he writes that "even in those countries which give legal sanction to the festive character of Sunday, changes in socioeconomic conditions have often led to profound modifications of social behavior and hence of the character of Sunday".

This, he said, would lead to "profound change".

Inhibition of mTOR leads to profound change in cellular metabolism and attenuation of protein synthesis.

This led to profound climate change.

Specialization in food habits has led to profound dental changes.

This led to profound changes for some of London's most venerable galleries.

The wide-scale transformation of California's ethnic mix has led to profound demographic changes.

This biodiversity loss has led to profound changes in the functioning of European agroecosystems over the last 50 years.

Subsequently, inhibition of COX-1 led to profound hypothermia whereas inhibition of COX-2 led to a normal hypothermic response.

These bone changes have led to profound reductions in bone density and bone mechanical strength [ 66].

This method led to profound increases in GCaMP3 fluorescence that saturated our detectors.