Sentence examples for led to extensive changes from inspiring English sources

Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages.

This transfer led to extensive changes in the metabolic and regulatory networks of these bacteria including the development of a novel carbon catabolite repression system.

Based on these arguments, we conclude that the changes induced in the case with which differently sized fish may migrate upstream past a partial migration barrier have led to extensive changes in the demographic structure of the population and potentially in the population dynamics.

Depletion of mDia1 led to extensive changes in cortical actin organization, with areas of high filament density alternating with large gaps (100 200 nm) devoid of actin filaments (arrowhead in Figure 3D), very different from the homogeneous mesh with a gap size of ∼30 nm observed in control conditions.

Many questions remain and the research is still under way, but this work could lead to extensive changes in social policy and the saving of millions of lives.

In addition, thermal stress can lead to extensive changes in gene expression [ 13- 16].

Activation of the HIF transcription factor signalling cascade leads to extensive changes in gene expression, which allow cells, tissues and organisms to adapt to reduced oxygenation.

Activation of the HIF signalling cascade leads to extensive changes in gene expression, which allow cells, tissues and organisms to adapt to reduced oxygenation.

Unfortunately, high mutation rates of influenza virus may lead to extensive changes in viral nucleic acid sequences making dedicated PCR primer use irrelevant; therefore, it is highly demanded to develop rapid and universal identification and detection technologies.

In addition, diagnostic inaccuracy is often prompted by infiltrative and displacing mass lesions and pathological signal alterations involving the pre- or postcentral gyrus, which can lead to extensive changes of anatomical proportions, partially or completely impeding presurgical neuroimaging.

We all agree that new technologies will lead to extensive change, not only in our business life but in all aspects of our social life.