Sentence examples for led to a subtle decrease from inspiring English sources

Intriguingly, in contrast to Mel-CVR cells, CREB knockdown only led to a subtle decrease in AEBP1 mRNA levels in Mel-CV cells.

These data are interpreted to mean that the cyclobutane ring of the T=T restricts the conformational flexibility of the loops that leads to a subtle decrease in stability without altering the overall fold for hybrid and basket G-quadruplexes.

But the passage of time has led to a subtle and worrying development.

It also led to a subtle change in the way government did business.

This has led to a subtle downgrading of the TV broadcasters.

For example, loss of Cdk5 led to a subtle impairment in fEPSP repolarization in the hippocampal SC/CA1 pathway.

Conditional deletion of Hdacs1,2 in fibrosarcoma cells led to a significant increase in H4K5ac, whereas deletion of Hdac3 led to a subtle increase in H4K5ac.

The latter only led to a subtle metabolic deficit, highlighting the vulnerability of retinal ganglion cells to even mild energetic imbalances.

A likely explanation is that Leu20 is located in the center of the ligand binding sites and a slight change in residue size (e.g., replacement with the slightly longer residue Met) might lead to a subtle distortion in the active site, which is sufficient to decrease the rate of steady-state turnover but because of its position does not affect substrate binding.

69 Its inhibition can lead to a subtle lowering of blood glucose levels.

A Dscam mutation in mice leads to a subtle defect in the caudal folium of the cerebellum [ 42].