Sentence examples for led to a marked decrease from inspiring English sources
The introduction of CT has led to a marked decrease in the rate of negative appendectomy, as much as 48% in one institution [12].
Moreover, compared with isotype control, anti-G-CSF mAb treatment demonstrated reduced MDSC accumulation, which led to a marked decrease in neoplasm size and number in mice.
These mutations led to a marked decrease in the overall thermodynamic stability of the evolved KE07s and in the configurational stability of their active sites.
Furthermore, the overexpression of an increasing dose of SENP3 in cells that expressed exogenous ubiquitin and endogenous SUMO2/3 led to a marked decrease of ubiquitin conjugations in a SENP3 dose-dependent pattern (Fig. 1B).
The highest diet digestibilities were measured for RC and PRG, whereas increasing inclusion of the whole-crop oat silage (0, 60, and 75% of forage DM) led to a marked decrease in diet digestibility (0.717, 0.624, and 0.574 g/g, respectively).
Following Ma-on's passage, temperatures decreased across Japan, which led to a marked decrease in heat stroke deaths.
The correction of respiratory acidosis was associated with rapid hemodynamic improvement, which led to a marked decreased in the need for norepinephrine.
Inadequate delivery combined with increased uptake leads to a marked decrease in the interstitial glucose levels during severe ischemia [23].
Higher values of the power-law index are found to lead to a marked decrease in the phase speed and a noticeable increase of the group speed of the extensional wave.
This possibility is supported by the finding that TSA treatment, which leads to histone hyperacetylation, leads to a marked decrease in nucleosome density at the vgQ-lacZ reporter.
All of the above effects can contribute to tumorigenicity and, in fact, ectopic expression in rat L6 myoblasts [16] or over-expression in human Caco2 colonocytes [10] of CEA and/or CEACAM6 prior to differentiation leads to a marked decrease in the latent period for tumor formation in nude mice.
