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Interestingly, however, despite substantial numbers of patients leaving trials, fewer patients on aripiprazole discontinued treatment compared with other antipsychotics, either due to insufficient clinical response, worsening of illness, or adverse effects.
After removing randomised controlled trials with different levels of attention or support to the low fat arms (leaving trials that worked to attain specific fat goals in the control group and those carried out in institutions or through trial shops), a statistically significantly greater reduction in weight in the lower fat arms (of −1.4 kg) remained (table 3).
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The extracted outcomes are illustrated in Figure 2. Right or left trials were selected for the statistical analysis based on the affected limb.
In patients receiving these newer agents, some RCTs have demonstrated nearly identical SVR12 and SVR24, 1, 2 and this has left trial researchers comfortable using SVR12 as the primary efficacy outcome.
Therefore, these two trials were excluded, leaving 40 trials (17 butterflies with eyespots painted over and 23 butterflies with visible eyespots) for further analysis.
We excluded this trial from our detailed analyses, leaving 190 trials overall (80 African and 114 North American) for further analysis.
Of these, two trials were duplicate publications [ 13, 21], leaving 12 trials with unique data.
Eight trials were reported in abstract or summary form only, leaving 118 trials reported in sufficient detail to extract information on the rationale.
Leaving jury trials to his close friend and partner James Coleman, Mr. Sloman focused on arguing matters of law and jurisprudence through motions, briefs, and appeals.
However, when treatment was longer than 12 weeks, there was no evidence of a difference in numbers of patients leaving the trials (Birks & Harvey 2003).
In this analysis, there were four EVs at the subject level: right visual field trials, left visual field trials, coactivation, and non-coactivation trials.
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