Sentence examples for least substitute from inspiring English sources

Liverpool's lack of threat will have alarmed Rodgers but at least substitute Jonjo Shelvey, on for debutant Nuri Sahin, was prepared to test Mannone, twice bringing saves with efforts from distance.

The thinking behind such programs is that if drug use can't be halted, at least substituting clean needles for dirty ones means that users face less exposure to diseases and infections.

The least substituted conjugates of PS 2 and the two MAb had tumour uptake values similar to the unconjugated antibodies.

7 The consistent trend of activating the least substituted, terminal olefin is proposed to also prevail in this reaction (Scheme 12).

The proposed catalytic cycle for a resin-bound trityl source is shown in Scheme 2. P2Pt2+ initiates the cyclization by coordination to the least substituted olefin.

Clearly, when conjugating PS 1 with MAb FSP 77 at initial molar ratios of 40 and 60, only the least substituted MAb is soluble enough to pass through the column.

These features coupled with the strong preference of Pt II) electrophiles to coordinate to and activate the least substituted alkene provide the means to achieve precision in the activation and propagation of cascade cyclizations.

In complex substrates with multiple alkenes, this preference ensures that the least substituted alkene is always the better ligand for the Pt II) initiator, and consequently the site at which all electrophilic chemistry is initiated.

Taken together with selective coordination to the least substituted, terminal olefin, we have come to believe that these effects account for why our Pt systems tend to fully cyclize without premature termination (Scheme 11).

In reactions with 3, the two metal species behaved similarly, with no partially cyclized products detectable, due in part to the propensity of Pd and Pt to coordinate and activate the least substituted, terminal alkene.

In the case of Tyr450, the π-chamber placed the least substituted end of the carbocation into the face of this aromatic ring, while the C2 C9 intermediate placed the methyl groups from the more substituted end into the face of this aromatic ring.