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Specific knockdown of Mcl-1 expression by RNA interference has been shown to be sufficient or at least required for the induction of apoptosis in different types of cancer cells.
Recently, by incorporating mutant INCENP, Xu et al. revealed that the full activation is at least required for transferring the CPC to the midzone at anaphase onset (Xu et al., 2009).
These results indicated that the simultaneous expression of OCT3/4, SOX2, and c-MYC was at least required for the transformation of AGM fibroblasts, while KLF4 did not play a major role in the transformation of AGM fibroblasts.
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The judge there said that part of the formula was flawed, or at least required further explanation for why the government made some of the choices it did.
In the United States, straight whiskeys are named for the grains predominating in the mash, with at least 51 percent required for whiskeys designated as straight.
These data suggested that the leucine zipper domain in optineurin is at least partially required for Rab8 binding.
This observation supports the idea that the degradation of tagged proteins is at least partially required for normal spore germination and sporulation at high temperature.
Our finding that all of the muscle-specific p38 MKO mouse lines had normal IIb-to-IIa fiber-type transformation may also suggest that PGC-1α function is at least not required for contractile adaptation.
These results establish that type I IFN signaling is at least partially required for 9cRA/poly(I C -triggered cI C -triggered
Since Bax was (at least partially) required for sorbitol-induced ΔΨm loss, we suspected that specific mitochondrial alterations might accompany the cell death triggered by hyperosmotic stress.
Comparison of single vs. multiple defects within muscle following RNAi revealed that kinases appear to be most frequently required to maintain proteostasis and least frequently required for normal sarcomere structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com