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The Bulls have constricted Brooklyn's options and diverted the action to its least potent offensive players.
Yet public attention focused almost entirely on the least potent part of the Fed's stimulus effort, its pledge to expand its holdings of mortgage bonds and Treasuries to increase job growth.
Active molecules are ranked ordered from most to least potent (left to right).
Fig. 8 Pharmacophore generation from most potent and least potent σ1 ligands.
Fig. 7 Molecular surfaces map for a spipethiane and most potent σ1 ligand, b spipethiane and least potent σ1 ligand and c most potent and least potent σ1 ligands.
Compound 5i was found to be the least potent among the active ligands with IC50value of 210.1 ± 0.29 μM.
Fig. 6 Superposition of spipethiane (cyan), the most potent (purple) and least potent (green) σ1 receptor ligands.
The structural analogs of clozapine, loxapine and amoxapine, both inhibited glucose transport with amoxapine being the least potent.
The highest IC50 value (22.6 mg/ml) was obtained when 741 was extracted with ethanol, which indicated its least potent antioxidant activity.
The superposition of spipethiane (cyan), the most potent (purple) and least potent (green) σ1 receptor ligands is shown in Fig. 6.
Discussion on the MEPs will be for spipethiane, the most potent (7e) and the least potent σ1 ligand (8d), illustrated in Fig. 7.
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