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AsF6− anion exhibits rotational disorder about the three crystallographic directions of which the y-direction is least hindered.

17S,20S-Methanofusidic acid is obtained by an efficient synthetic route including cyclopropanation of the Δ17(20) bond with attack solely from the least hindered α-face.

(ii) The sterically least hindered prim-OH group of sugars can be selectively oxidised by copper-containing galactose oxidase (Scheme  12).

If the ends of the molecule are not fixed (or at least hindered), the supercoiling will dissipate via the unhindered rotation of the helix.

The significantly lower inhibition values for 1 and 3 are particularly interesting since in this study these two silanetriols are the more sterically shielded ones while 2 is the least hindered congener.

The highest inhibition rate was found for the sterically least hindered cyclohexylsilanetriol with 45% inhibition relative to galanthamine hydrobromide for which an IC50 value of 121 ± 3 μM was determined as well.

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How do we keep going in the face of what is intended to destroy us – or at least hinder our progress?

The measure, which had immediate effect, was in keeping with a dramatic series of executive actions that Obama has taken to solidify as many of his policies as possible, or to at least hinder their reversal by Donald Trump.

But now there are lots of questions: how could he make such pictures while at the same time selling information he knew might hurt or at least hinder those fighting to end the oppression?

After a couple of weeks of posturing - with authors, publishers and Ottakar's itself all rounding on HMV chief exec Alan Giles (who also runs Waterstone's) they now have to get down to the job of trying to block, or at least hinder, Giles's carefully manoeuvred bid.

Therefore, dams are suggested to effectively stop, or at least hinder, the advance of invasive crayfish.

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