The phrase "least familiar with" is correct and usable in written English.
You can use it when you want to compare two or more things and explain which one you are the least familiar with among them. For example: "I'm most familiar with Spanish, but I'm least familiar with French."
American readers will be least familiar with Hilde Spiel.
Some players are oblivious to the method of listening to the bats' vibrations, but others are at least familiar with it.
He is the Tennessee staff's third assistant, the X's and O's guy, the one farthest from the spotlight and least familiar with the carnival of the recruiting trail.
Still, the influx of oil money and the Western orientation of Mr. Aliyev's government mean a majority of people are at least familiar with the Latin alphabet.
The news of police involvement with the Loughners suggests that county sheriff's deputies were at least familiar with the family, even if the reason for their visits was unclear as of Tuesday night.
Many fundamentalists still accept the dispensationalist view — the late Jerry Falwell was a dispensationalist, as is the Reverend Pat Robertson — and many more are at least familiar with its themes.
So how could Damore have chosen them if he wasn't at least familiar, and likely aligned, with their views?
The quartet began with the least familiar of its four works, Schulhoff's Quartet No. 1 (1924) and made a powerful case for it.
"People who have a growing amount of influence are people who can at least speak in business terms or at least be familiar with that way of thinking".
However: Farwich at least looks familiar with pint pouring dynamics.
Any reader the least bit familiar with epidemiology should be deeply suspicious of this work….
