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It's what plays us least false.
Eyes were watching, and therefore "our position is a very delicate one; the least false step, at a moment like the present, may tell a dismal tale".
However, the proposed FDS exhibits optimal performance in Profile 3 by claiming maximum (mathrm{Specificity} = 88.46%) (i.e., least false acceptance rate).
She cites a number of cases in which science has progressed from one theory to a better theory where, we would say, understanding has increased in the process even though the theories are, strictly speaking at least, false.
* A lot of the statements in the above – that buying £200 worth of scratchcards is a brilliant idea, that the stock market is trash, that true investment can only be made while holding an old coin and scratching your heart out on a table in the back of a Wetherspoons in Romford – are at least false and at worst actively dangerous.
Here, the threshold of ArathMitoP LR (Likelihood Ratio) is set at 1.37, so that the integrated predictions achieve the least false positives rate (2.53%) and the largest coverage of true predictions (84.67%) based on the comparison with GSN∼mito and GSPmito at the same time (Fig. 1, and Fig. 2).
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The high threshold represents the most conservative annotation approach (with the least false-positives), followed by a gradual reduction in stringency, including medium-high, medium-low, and low thresholds.
The third category to be investigated consisted of the suboptimal solutions that fixed at least one false negative while producing no new false positives.
Category I solutions were optimal solutions that eliminated at least one false negative condition while creating no new false positives.
A previous approach to estimate the probability of at least one false positive in n screenings unrealistically assumed that the probability of dropout does not depend on prior false positives.
Although only 2-3 of 35 simulated datasets (5.7-8.6 5.7-8.6ded at least one false positive, this proportion was higher for the empirical datasets (2/5 = 40% under both thresholds).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com