For further hierarchical clustering based on BP GO terms, we first collated all the GO terms obtained after the enrichment, and the filtered for those GO terms which were at least enriched in one the of time points with adjusted P-value < 0.05.
At its broadest, the paper is motivated by the assumption that evaluating any plausible pedagogical methodology might, at the very least, enrich the field's knowledge about cognition and instruction (Easterday, Rees Lewis, & Gerber, 2016).
In addition, comparison of male and female antennal extracts may identify putative PBPs, which in most cases are specifically expressed or at least enriched in male antennae.
Indeed, Scp160 and Npl3 appear to interact with almost the entire transcriptome, and ASH1 mRNA was among the RNAs least enriched by affinity purification of Scp160 or Npl3 [5].
We ranked the 7805 (for miR-1-transfected cells) and 7817 (for miR-124-transfected cells) well-measured mRNAs with RefSeq IDs from most enriched to least enriched in Ago2 IPs (Figure 7A and B, x-axes).
Least enriched is the low impact missense mechanism.
Another CC annotation, 'mitochondrion', was most enriched in the obesity/metabolic syndrome and neurological portals, and was least enriched in the cancer, respiratory disease and immune portals.
Enriched regions were defined from enriched probes (Z-score >= 6) using the following criteria; (i) at least 2 enriched probes within the region, (ii) each enriched probe must be flanked on both sides by existing measurements within 110 base pairs (iii) the maximum gap between enriched probes within a region is 110 base pairs.
The results are presented in Figure 3, which depicts the number of modules with at least one enriched set in the MSigDB enrichment analysis and the total number of unique enriched gene sets.
To validate the biological significance of the clusters, we first counted the number of Gene Ontology (GO) terms enriched in the clusters and the percentage of clusters that had at least one enriched GO term, at various significance levels.
