Sentence examples for least differentiated from inspiring English sources
On encountering antigen CD8+ T cells differentiate from the least differentiated (naïve or early memory) stage to the most mature (memory/effector) stage.
Similarly, the grade of differentiation was associated with changes in methylation only in the least differentiated tumors (grade 3) (data not shown).
Since there is a range of differentiation within each intrinsic subtype (Fig. 4b), we tested if the least differentiated basal-like/claudin-low tumors were more metastatic than the more differentiated basal-like/claudin-low tumors.
During development and possibly during repair, cells undergo a sequence of hierarchical transcriptional events that mark the transition of these cells from the least differentiated urothelial phenotype characteristic of the basal cell layer, to the most differentiated cellular phenotype characteristic of the superficial cell layer.
Classifications that are not based on family trees usually involve ranking languages according to degree of differentiation rather than grouping them; thus, if the Romance languages are compared with Latin, it is seen that by most measures Sardinian and Italian are least differentiated and French most (though in vocabulary Romanian has changed most).
Lack of cell movement means that each lineage represents a developmental time line, with the least differentiated cells being closest to the niche.
Furthermore, the relative abundance of different TDLU morphotypes in the human breast can influence breast cancer risk, where the least-differentiated TDLU type 1 (TDLU-1) is most prone to transformation [ 17].
In the latter case Oberon should be at least partially differentiated, with the ice crust lying atop the non-differentiated interior.
The kidney is a complex organ that consists of at least 26 differentiated cell types.
However, most cells are produced postembryonically in, at least partly, differentiated organs.
In the case of the HNF1B gene, the conditional deletion was been carried out in adult (or at least partly differentiated) mouse islets, since the insulin gene was used to target the beta cells for gene knockout [8].
