For the cruciform bending (CRB) specimen, the constraint at the crack tip surface shows a least constraint while the deepest point has a relatively higher constraint.
The least constraint value function is used as in the definition of sats to guarantee that context reduction is a decidable relation.
During TKA requiring the use of a femoral augment or stem extension, the design offering least constraint can be chosen, and an LCCK prosthesis with a PS polyethylene insert could be a satisfactory option.
While our work did not entail identifying positively selected Plasmodium genes, the genes with the least constraint on their coding regions included the regulatory transcription factors and CCCH zinc fingers and parasite lifestyle-associated cell invasion and sexual development genes.
Regions of open chromatin display the lowest mutation rates and the least constraint at the synonymous sites of genes.
However, unlike Drosophila, where UTRs showed the strongest selection of the noncoding regions, pea aphid UTRs exhibit the least constraint of the noncoding DNAs.
The main conclusion from this study is that 4-fold degenerate sites of avian genes evolve under significant constraint, at least when constraint is estimated using divergence in ARs as a neutral reference.
Last but not least, financial constraints played a part.
