Sentence examples for least alteration from inspiring English sources

As the side-chains of His and Gln are similar in both molecular size and ability to participate in hydrogen-bond as a proton donor/acceptor, this substitution is expected to make the least alteration on protein's functionality from physiochemical point of view.

The mutant with the least catalytic activity, E354A, also displayed the least alteration in apparent substrate affinity of BAT1-mediated transport compared with oocytes expressing BAT1 alone or BAT1 and collectrin.

With 276 differentially regulated transcripts, PC346DCC showed the strongest divergence from the parental line, whereas PC346Flu2 revealed the least alterations (127 transcripts).

Our aim was to include these components with the least alterations to the Drosophila model in a way that all key experimental observations in control and MO experiments in Nematostella could be reproduced and thus generate a minimal viable model of BMP signaling maintenance in Nematostella after symmetry break (see the Supplemental Experimental Procedures for details).

Using a battery of informatics tools to identify single nucleotide variants, insertions and deletions, and amplification (including variants EGFRvIII and EGFRvV), twenty-one of the 34 (62%) individuals had at least one alteration in EGFR by sequencing, consistent with published datasets.

I believe climbers should leave the rock as unaltered as possible ... you have a responsibility not only to put in safe bolts but to put them in logical places to do the least possible alteration of the rock to establish the best possible experience for others".

In total, 83% of the tumours had at least one alteration at 11p15.5 and/or 11p13.

Due to the wide use of gene expression microarray technology, almost all of these genes show at least one alteration regarding the transcriptome.

Patients having at least one alteration in the PI3K pathway show a borderline significant association with SCC RRR = 2.01, 95% CI 0.94 4.30, P =  0.02; Table  4).

In addition, the most frequent underlying diseases were diabetes and hypertension, both of which suggest at least an alteration of vascular control.

If confirmed by future studies, loss of Shank in placozoans would imply disruption or at least considerable alteration of the macromolecular architecture of the PSD-like protein complex.