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In the study recommended by the reviewers (Wirth, Yanike, et al., 2003), and a subsequent article with many of the same authors (Smith, Frank, et al., 2004), we found an analysis algorithm that allowed us to address the problem of rigorously identifying the learning trial for each mouse.
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Learning trials for psychomotor vigilance testing were conducted and functional movement assessments were performed.
For each mouse, we carried out three learning trials per day for nine successive days.
Note that the confidence interval is narrower for M = 100, and, as a result, the IO 0.95) learning trial occurs earlier in the trial for M = 100 (trial 14) vs. M = 1 (trial 23). Figure 9D shows this trend for a range of M between 1 and 1,000.
The present study examined the effect of massed versus spaced learning trials on 24-hour delayed recall for a visuospatial learning task.
To answer that, we used a habituation dishabituation test, exposing mice to d-limonene for five successive learning trials and then to decanal for the discrimination test (Fig. 5D).
To avoid punishing the monkey for his inescapable response latencies in learning trials, fixation requirements were suspended for the 250 ms between the onset of target motion and the time of the instructive change in target motion.
We applied a protocol that is shown to specifically induce all phases of LTM formation [26] with inter-trial intervals of 15 min. Prior to learning trials, all individuals were tested for responsiveness by touching the antennae with a droplet of 20% sucrose.
Across subjects, the mean number of learning trials needed to reach the learning criterion for both of the actively learned melodies was 20.5 (range 10 to 40 trials).
There was no significant difference between the number of learning trials for the passively learned melodies (i. e. 10 trials for each melody) and the number of learning trials for the actively learned melodies (sign test, p>0.3).
Two participants needed more and two subjects fewer learning trials for the second as compared with the first melody.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com