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All animals were trained in a task that requires intact hippocampal function for learning, consolidation and recall [34] as well as hippocampal LTP maintenance by persistent activation of PKMζ for long-term memory storage [42], [55].
This lack of effect on memory retrieval is in stark contrast to the dramatic and detrimental effects of the NMDA receptor knockout on learning, consolidation, and storage [10] [13], [17], [18].
Because it is well known that the NMDA receptor is required for learning, consolidation and storage [9], it is possible that the performance deficits observed in CA3-specific knockout mice under the partial-cue condition might have well reflected weak binding of various memory traces during the acquisition and consolidation stages due to the lack of the NMDA receptor during those stages.
83, 84 Limited daily feeding enhances learning consolidation and synaptic plasticity by a mechanism involving increased expression of the NR2B subunit of the NMDA receptor.
Ro 04-6790 also reversed impairment in learning consolidation produced by the NMDA receptor antagonist MK-801, and the antagonist PRX-07034 restored the impairment of novel object recognition in the social isolation rearing model, both of which showed behavioral changes that resemble the core defects observed in schizophrenia [ 11].
We believe our study to be the first to investigate implicit learning consolidation in autism.
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The role of international advocacy, learning, sharing, consolidation of power... That's the role of powerful, global NGOs now".
We develop an algorithm for learning and consolidation of motor memory and study the space complexity of the representation in the experiments with humanoid robot Nao.
In motor learning, training a task B can disrupt improvements of performance of a previously learned task A, indicating that learning needs consolidation.
During this period, if the cellular network is reengaged in another session of learning then consolidation of the first task will be disrupted.
In other words, due to distinct circuitry properties in memory processes, CA1 NMDA receptor is mostly involved in learning and consolidation, whereas, CA3 may be preferential for pattern completion during recall.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com