In this study, we identified six highly lean-specific modules and five highly obese-specific modules in the prenatal animals (Additional file 1: Table S6 and Table S7).
A greater number of hub genes related to myogenesis were detected in the lean-specific modules compared with in the obese-specific modules.
In lean-specific modules, a hub gene in Lde-salmon, STAT5B, was reported to be critical for normal postnatal growth [ 57].
Among the genes with known functions, 17 hub genes related to muscle development were found to play major roles in the six lean-specific modules.
Nonetheless, six highly lean-specific modules and five highly obese-specific modules were identified in the prenatal LT and Lde animals, indicating that prenatal myogenesis was significantly different in the two breeds.
Only two modules were common between lean and obese postnatal animals; however, about 15 highly lean-specific modules and 13 highly obese-specific modules were identified (Additional file 1: Table S10 and Table S11).
In contrast, our analysis of 15 lean-specific modules and 13 obese-specific modules containing 2504 genes revealed a molecular regulation mechanism that was associated with the different muscle phenotype in the two breeds.
These results suggest that the lean-specific modules cover all the main processes of postnatal muscle development, including muscle cell proliferation and differentiation, secondary muscle growth, postnatal muscle growth for fiber composition, development of the vascular and circulatory system, and muscle function regulation.
For example, the hub genes MYL1 [ 48], TNNT3 [ 49], and MYH2 [ 50] in the lean-specific modules, encode proteins that are critical for fast fiber differentiation, and TPM2 [ 51] and MYLPF [ 52] have been reported to be critically important for fast and slow skeletal muscle development.
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