Exact(1)
Hyperinsulinemia initially present in obese rats at 2 months (10.5 ± 0.7 μg/L plasma insulin vs 0.2 ± 0.04 μg/L in lean) decreased due to ß-cell insufficiency at 3 months (3.9 ± 0.6 vs. 0.5 ± 0.09 μg/ml in lean).
Similar(59)
With castration, the internal fat and carcass fat content increased and carcass lean content decreased.
In contrast, inhibition of myostatin signaling in skeletal muscle, like Mstn deletion, resulted in increased lean mass, decreased fat mass, improved glucose metabolism on standard and high-fat diets, and resistance to diet-induced obesity.
Serum amylase levels in lean subjects decreased significantly with advancing grade of NAFLD, whereas those in obese subjects did not.
The proportion of body weight made up of fat mass was increased, whereas the proportion of lean mass decreased.
BACE1 −/− mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild-type littermates.
Bone, muscle and fat measures at all four testing sessions are presented in table 2. Controlling for age, weight, dietary energy intake, calcium consumption and past physical activity, lean mass decreased at each measurement time point throughout the 2009 season, but returned to pre-2009 season values by 2010 preseason (mean difference=0.230, 95% CI −0.987 to 1.168 kg; p=0.86).
27 An anticatabolic effect of nutritional supplements (containing 2510 kJ, complete macro-and micronutrients) combined with dietary counseling in HIV-infected subjects was reported by Berneis et al. 28 The diminished whole body protein catabolism resulted in a change of body composition (increased lean mass, decreased fat mass).
Their data indicated that the neurotoxic effects of METH in lean mice (decreased striatal DA and TH protein as well as an increase in glial fibrillary acidic protein) were exaggerated in the obese mice, thus implicating obesity as a risk factor for susceptibility to neurotoxic insult (Sriram et al. 2002).
The specific outcomes of working with Lean were decreasing waiting time for the patients, optimised workflow during the examinations, and an increased number of patients processed during a working day with only a marginal increase in costs.
Overall, these results demonstrate that both fat mass and lean mass were decreased in the TG males, but that fat mass was decreased more than lean mass.
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