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In particular, the db/db mice showed few positive cells compared to lean control mice in all cortical layers.
Average BMI of the lean control subjects was 23.0 kg/m23.0
Serum adiponectin levels were 1.4-fold decreased in LepOb mice compared to lean control mice.
A lean control individual was defined as having a BMI less the 25 kg/m25
A major difference was the relative increase in M. smithii in anorexic patients compared to the lean control group (Figure 5; p = 0.0171).
The anorexic bacterial profile is similar to the lean control group for the Firmicutes, Bacteroidetes, and Lactobacillus but different for M. smithii (anorexic group had higher quantification).
In our study, the young and aging ob/ob mice exhibited significantly greater fat composition, heavier body and heart weights compared with the age-matched lean control group.
The results of this group were similar to the lean control group for Bacteroidetes (Figure 3), Firmicutes (Table 2), and Lactobacillus (Table 2 and Figure 4).
More detailed analysis of EWAT revealed that several genes whose expression is increased in LepOb mice compared to lean control mice, decreased following lowering of glycosphingolipid content.
Furthermore, PWS subjects, on average, ate three times more calories to attain a similar feeling of decreased hunger as did a lean control group [42], [48].
To address this directly, we investigated intracellular TGFβ1 production in skin γδ T cells isolated from wounded lean control and obese animals.
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