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In pathological conditions in which the cerebrovascular integrity is perturbed such as neuroinflammatory diseases and Alzheimer's diseases (Bell et al., 2012; Sengillo et al., 2012), taking advantages of platelets as a vehicle to transfer druggable materials into the leaky area may become a translational approach.
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For both companies, the partnership is an opportunity to plug up leaky areas.
Systemic cytokines can affect the brain through several mechanisms, including active transport across the blood brain barrier [ 103], through leaky areas in the blood brain barrier in the circumventricular organs [ 104] or through the activation of neural pathways such as the vagal nerve [ 105].
We take them to a large, open, dingy, leaky storage area.
As another consequence of VEGF gene transfer, the newly formed vessels were leaky, and the area of transfer was surrounded by oedema compared to animals treated with AdHIF-1 α and AdHIF-2 α [ 91].
In March, department officials discovered that some properties in the area had leaky connections to the main sewer, and ordered the owners to repair them.
Micelle passive accumulation in the areas with leaky vasculature (tumors, infarct zones) is discussed as an important physiology-based mechanism of drug delivery into certain target zones.
FEVR is a genetically heterogeneous eye disease characterized by incomplete and abnormal retinal vascularization, which also displays ischemic areas and leaky vessels in the retina.
In areas with leaky sewers the results from WWA may tend towards an underestimation of actual illicit drug loads.
We also observed a heterogeneous microenvironment consisting of blood vessels, individual red blood cells associated with the leaky vessels, and necrotic areas containing inflammatory cells.
(City Park's Hopper disputes the "wetlands" designation as misleading, because it did not refer to historical water tables but an area where a leaky pipe had created wetlands conditions in recent years).
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