Sentence examples for leak function from inspiring English sources

Mutations in presenilin interfere with this leak function, and result in greater Ca2+ filling and release from ER (Tu et al., 2006).

It has been found that presenilins act as calcium leak channels in the endoplasmic reticulum of hippocampal neurons and many PSEN1 mutations impair this leak function, resulting in endoplasmic reticulum calcium overload and supranormal calcium release.

Although the attenuating effect of UCP2 activity on glucose-stimulated coupling efficiency (Fig. 2B) and mitochondrial ROS production (Fig. 4) agrees with a primary proton leak function, it is possible that a different UCP2 activity accounts for these phenotypes.

KChIP3 is known to interact with presenilin-1 and -2 and the presenilins have been shown to potentially affect [Ca2+]i through an effect on ER Ca2+ by having a Ca2+ leak function [ 39].

PURPOSE: To estimate the prevalence and identify factors related to late-onset transconjunctival aqueous oozing and point leak from functioning blebs after trabeculectomy with 5-fluorouracil (5-FU) or mitomycin C.

Tunicamycin 20  μg/ml significantly decreased mitochondrial oxidative-phosphorylation (Ox-Phos) and reserve oxidative capacity (reserve-capacity) after 1 h and 2 h of treatment, whereas proton leak, which functions to dampen ROS generation, was increased at 1 h but decreased significantly at 2 h of treatment.

The exercise-induced reduction in oxygen wasting associated with EC coupling can be related to reduced RyR2 Ca2+ leak, improved SERCA2a function and normalization of SL Ca2+ transport, and synchronization of SR Ca2+ release.

As we did not measure Ca2+ directly, our study relies on previous observations showing that SR Ca2+ leak is a function of SR Ca2+ load [ 29] and that SR Ca2+ concentration in intact cardiac myocytes depends directly on intracellular Ca2+ concentration [ 23].

Off label applications include evaluation of biliary disorders, bile leaks and hepatic function.

To our knowledge, no direct measurements of SR-Ca2+-leak as a function of late INa have been performed in atrial CMs.

Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death.