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The affinity of the new cloned antibodies is improved by mutations, which in turn, leads to neutralisation and elimination of the antigen.
The addition of an acetyl moiety to the side-chain nitrogen of lysine leads to neutralisation of charge, which can significantly influence protein conformation and protein protein interactions, thus resulting in the modulation of enzyme activities and protein assembly (Ref. 1).
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Exceeding this limit might lead to a neutralisation of the positive effect of the nanoparticles. .
Exceeding this limit might lead to a neutralisation of the positive effect of the nanoparticles.
This neutralisation of positive charge leads to a loosening of the histone:DNA structure, allowing access of the transcriptional machinery; furthermore, the acetyl groups may associate with and recruit factors containing bromodomains [ 11].
Bioleaching of sulphide concentrate leads to two types of solid waste: a ferrihydrite/gypsum precipitate from neutralisation of the bioleach liquor and un-leached gangue.
Similarly, Webb et al (2000) showed that neutralisation of receptors in LDL receptor family (LRF) leads to inhibition of catabolism of uPA and uPAR, resulting in increased binding of endogenously produced uPA to uPAR and the enhancement of basal level of activated Erk.
The high mutation rate that occurs during replication of the virus and selection of neutralisation-escape variants by pre-existing antibodies, leads to the virus undergoing "antigenic drift" within populations, such that a particular influenza vaccine usually confers protection for only a few years.
The neutralisation experiments showed that the lack of IL-17 leads to decreased neutrophil emigration and systemic granulopoietic responses to pulmonary bacterial pathogens and allergens.
The in vivo neutralisation of these cytokines using the appropriate antibodies or decoy receptors leads to significant amelioration of signs and symptoms of joint inflammation [ 2, 6, 7].
Neutralisation of gastrin in an INS-GAS mouse in vivo carcinogenesis model leads to reduced proliferation and MMP-7, Slug and HB-EGF expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com